Ethanol → 6-Ethoxyimidazo[1,2-b]pyridazine

HRID 1607305노트

반응식

HRID 1607305 반응식
[Na].Cl[C:3]1[CH:4]=[CH:5][C:6]2[N:7]([CH:9]=[CH:10][N:11]=2)[N:8]=1.[CH2:12]([OH:14])[CH3:13]>>[CH2:12]([O:14][C:3]1[CH:4]=[CH:5][C:6]2[N:7]([CH:9]=[CH:10][N:11]=2)[N:8]=1)[CH3:13]

참가 물질

4

반응물 3

HCID 702EthanolHCID 138828Imidazo(1,2-b)pyridazine, 6-chloro-HCID 5360545Sodium

생성물 1

HCID 200766186-Ethoxyimidazo[1,2-b]pyridazine

실험 절차

Sodium metal (0.55 g) is dissolved in 30 ml of ethanol and, to the solution, is added 3 g of 6-chloroimidazo[1,2-b]pyridazine and the mixture is heated under reflux for 3 hours. The solvent is then evaporated off under reduced pressure and the residue is dissolved in water and the mixture is extracted with methylene chloride. The extracts are combined, washed with saturated solution of sodium chloride and dried over MgSO4. The solvent is then evaporated to give 3.3 g of the title compound as colorless crystals.

후처리

  1. temperaturethe mixture is heated
  2. temperatureunder reflux for 3 hours
  3. customThe solvent is then evaporated off under reduced pressure
  4. dissolutionthe residue is dissolved in water
  5. extractionthe mixture is extracted with methylene chloride
  6. washwashed with saturated solution of sodium chloride
  7. dry with materialdried over MgSO4
  8. customThe solvent is then evaporated

출처 및 근거

ORD 기록
ord-cc4b1b9e1ec64f1e9032a1ad26118330
출처 데이터셋
uspto-grants-1989_09
특허 번호
US04864022

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