Dimethyl Sulfate → 1,2-Dimethyl-1H-imidazole-5-carboxylic acid

HRID 1607312노트

반응식

HRID 1607312 반응식
S(OC)(OC)(=O)=O.[CH3:8][N:9]1[C:13]([C:14]([O:16]C)=[O:15])=[CH:12][N:11]=[C:10]1[CH3:18]>>[CH3:8][N:9]1[C:13]([C:14]([OH:16])=[O:15])=[CH:12][N:11]=[C:10]1[CH3:18]

참가 물질

3

반응물 2

HCID 6497Dimethyl SulfateHCID 14344426Methyl 1,2-dimethyl-1H-imidazole-5-carboxylate

생성물 1

HCID 233618731,2-Dimethyl-1H-imidazole-5-carboxylic acid수율 67%

실험 절차

In the manner described in Example 1 126 g (1 mol) of 2-methylimidazole-4(5)-carboxylic acid was treated with dimethyl sulfate and the product was converted into its methyl ester for characterization. This gave 103.3 g of methyl 1,2-dimethylimidazole-5-carboxylate, m.p. 38°-40° C., an overall yield of 67%.

출처 및 근거

ORD 기록
ord-eed292a70e304ba7b0b778555e3424ad
출처 데이터셋
uspto-grants-1989_09
특허 번호
US04864030

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