Morpholine → 4-[(4-Bromo-2,5-difluorophenyl)sulfonyl]-morpholine

HRID 16074

반응식

HRID 16074 반응식
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Br:7][C:8]1[C:13]([F:14])=[CH:12][C:11]([S:15](Cl)(=[O:17])=[O:16])=[C:10]([F:19])[CH:9]=1>ClCCl>[Br:7][C:8]1[C:13]([F:14])=[CH:12][C:11]([S:15]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)(=[O:16])=[O:17])=[C:10]([F:19])[CH:9]=1

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 5745904-Bromo-2,5-difluorobenzenesulfonyl Chloride

생성물 1

HCID 686063584-[(4-Bromo-2,5-difluorophenyl)sulfonyl]-morpholine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Morpholine (0.16 ml) was added to a stirred solution of 4-bromo-2,5-difluoro-benzenesulfonyl chloride (0.18 g) in dichloromethane (6 ml) under nitrogen. The reaction mixture was stirred overnight and then quenched with water. The organic phase was dried (MgSO4) and concentrated in vacuo to give the sub-title compound as a white solid (200 mg).

후처리

  1. customquenched with water
  2. dry with materialThe organic phase was dried (MgSO4)
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-39a68fdc2cf342168e2bccff054cfd0b
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737135B2

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