Potassium Carbonate → 2-(Oxiran-2-yl)benzene-1-sulfonamide

HRID 1607789

반응식

HRID 1607789 반응식
[CH:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9]([NH2:12])(=[O:11])=[O:10])=[CH2:2].C(=O)([O-])[O-:14].[K+].[K+]>C(Cl)(Cl)Cl>[O:14]1[CH2:2][CH:1]1[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9]([NH2:12])(=[O:10])=[O:11]

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 113674032-Ethenylbenzenesulfonamide

생성물 1

HCID 138845232-(Oxiran-2-yl)benzene-1-sulfonamide

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A solution consisting of 2-ethenylbenzenesulfonamide (1.5 g, 8.1 mmol) m-chloroperbenzoic acid (1.4 g, 8.1 mmol) and potassium carbonate (1.1 g, 8.1 mmol) in 150 ml of chloroform was stirred for 4 days at room temperature. The reaction was filtered and the filtrate was washed with saturated sodium bicarbonate. The organic layer was separated, dried and concentrated. The resulting oil was flash chromatographed (methylene chloride) to yield the subject compound as a white solid. m.p. 136°-139° C.

후처리

  1. filtrationThe reaction was filtered
  2. washthe filtrate was washed with saturated sodium bicarbonate
  3. customThe organic layer was separated
  4. customdried
  5. concentrationconcentrated
  6. customchromatographed (methylene chloride)

출처 및 근거

ORD 기록
ord-589e1cb3c2544f2c8cbc5de97132190a
출처 데이터셋
uspto-grants-1989_09
특허 번호
US04867783

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