Benzoyl Peroxide → 3-(Bromomethyl)-1,2,4,5-tetrafluorobenzene

HRID 1607928

반응식

HRID 1607928 반응식
[F:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[C:4]([F:10])[C:3]=1[CH3:11].[Br:12]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[F:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[C:4]([F:10])[C:3]=1[CH2:11][Br:12]

참가 물질

5

반응물 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 788962,3,5,6-Tetrafluorotoluene

생성물 1

HCID 1043773-(Bromomethyl)-1,2,4,5-tetrafluorobenzene

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

반응 조건

온도
25 °C

실험 절차

A mixture of 2,3,5,6-tetrafluorotoluene (1.7 g), N-bromosuccinimide (1.9 g), dry carbon tetrachloride (10 ml) and benzoyl peroxide (0.01 g) was heated at the reflux temperature for 20 hours, cooled to the ambient temperature (ca. 25° C.) filtered and the filtrate diluted with diethyl ether. The ethereal solution was washed with water, dried over anhydrous magnesium sulphate and concentrated by evaporation of the solvents to yield 2,3,5,6-tetrafluorobenzyl bromide as a mobile colourlessoil.

후처리

  1. temperaturewas heated at the reflux temperature for 20 hours
  2. filtrationfiltered
  3. additionthe filtrate diluted with diethyl ether
  4. washThe ethereal solution was washed with water
  5. dry with materialdried over anhydrous magnesium sulphate
  6. concentrationconcentrated by evaporation of the solvents

출처 및 근거

ORD 기록
ord-1e894d1a67874e6783eab0da040c1559
출처 데이터셋
uspto-grants-1989_09
특허 번호
US04868209

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