4-Amino-5-chloro-2-methoxybenzoic acid → 4-amino-5-chloro-N-[[4-(4-cyanobenzyl)-2-morpholinyl]methyl]-2-methoxybenzamide

HRID 1608191노트

반응식

HRID 1608191 반응식
[NH2:1][CH2:2][CH:3]1[O:8][CH2:7][CH2:6][N:5]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]#[N:17])=[CH:12][CH:11]=2)[CH2:4]1.[NH2:18][C:19]1[C:27]([Cl:28])=[CH:26][C:22]([C:23](O)=[O:24])=[C:21]([O:29][CH3:30])[CH:20]=1.Cl.C(N=C=NCCCN(C)C)C>ClCCl>[NH2:18][C:19]1[C:27]([Cl:28])=[CH:26][C:22]([C:23]([NH:1][CH2:2][CH:3]2[O:8][CH2:7][CH2:6][N:5]([CH2:9][C:10]3[CH:15]=[CH:14][C:13]([C:16]#[N:17])=[CH:12][CH:11]=3)[CH2:4]2)=[O:24])=[C:21]([O:29][CH3:30])[CH:20]=1

참가 물질

5

반응물 3

HCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 148818422-Aminomethyl-4-(4-cyanobenzyl)morpholine

생성물 1

HCID 30870114-amino-5-chloro-N-[[4-(4-cyanobenzyl)-2-morpholinyl]methyl]-2-methoxybenzamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
25 °C

실험 절차

To a solution of 2-aminomethyl-4-(4-cyanobenzyl)morpholine (1.5 g) in dichloromethane (40 ml), 4-amino-5-chloro-2-methoxybenzoic acid (1.2 g) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (1.3 g) are added, and the resulting mixture is stirred at 25° C. for 3 hours. The reaction mixture is washed successively with water, aqueous sodium hydroxide solution and saturated aqueous sodium chloride solution, and dried over magnesium sulfate. The solvent is distilled off under reduced pressure to give the title compound as an oil.

후처리

  1. washThe reaction mixture is washed successively with water, aqueous sodium hydroxide solution and saturated aqueous sodium chloride solution
  2. dry with materialdried over magnesium sulfate
  3. distillationThe solvent is distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-30d972dfa3644820a4982b54e0d25ab2
출처 데이터셋
uspto-grants-1989_09
특허 번호
US04870074

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