Hydrazine hydrate (1:1) → Ethyl 2-(aminomethyl)morpholine-4-carboxylate
반응식
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][N:13]2C(=O)C3=CC=CC=C3C2=O)[CH2:7]1)=[O:5])[CH3:2].O.NN>C(O)C>[NH2:13][CH2:12][CH:8]1[O:9][CH2:10][CH2:11][N:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH2:7]1참가 물질
4
실험 절차
A mixture of N-[(4-ethoxycarbonyl-2-morpholinyl)methyl]phthalimide (10.0 g), 85% hydrazine hydrate (2.9 g), and ethanol (10 ml) is refluxed with stirring for 10 minutes. The reaction mixture is filtered and the filtrate is extracted with chloroform. The organic layer is washed successively with water and saturated aqueous sodium chloride solution, and dried over magnesium sulfate. Removal of the solvent under reduced pressure gives the title compound (5.8 g) as an oil.
후처리
- temperatureis refluxed
- filtrationThe reaction mixture is filtered
- extractionthe filtrate is extracted with chloroform
- washThe organic layer is washed successively with water and saturated aqueous sodium chloride solution
- dry with materialdried over magnesium sulfate
- customRemoval of the solvent under reduced pressure
출처 및 근거
- ORD 기록
- ord-d5e7ea2101ec49bdb961c19b407af6f1
- 출처 데이터셋
- uspto-grants-1989_09
- 특허 번호
- US04870074
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