Dimethyl Sulfoxide → 4-Benzyl-2-morpholineacetonitrile

HRID 1608215노트

반응식

HRID 1608215 반응식
[CH2:1]([N:8]1[CH2:13][CH2:12][O:11][CH:10]([CH2:14]Cl)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C-:16]#[N:17].[K+].CS(C)=O>O.[I-].[K+]>[CH2:1]([N:8]1[CH2:13][CH2:12][O:11][CH:10]([CH2:14][C:16]#[N:17])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 3

HCID 679Dimethyl SulfoxideHCID 9032Potassium CyanideHCID 28015624-Benzyl-2-(chloromethyl)morpholine

생성물 1

HCID 32484164-Benzyl-2-morpholineacetonitrile수율 92.8%

시약·촉매·용매 2

HCID 4875Potassium Iodide촉매HCID 962Water용매

반응 조건

온도
120 °C

실험 절차

A mixture of 4-benzyl-2-chloromethylmorpholine (22.5 g), potassium cyanide (13 g), potassium iodide (1 g), and dimethyl sulfoxide (40 ml) is heated with stirring at 120° C. for 5 hours. The reaction mixture is cooled, diluted with water, and extracted with diethyl ether. The organic layer is washed with water, dried over sodium sulfate, and evaporated to give the title compound (20 g) as an oil.

후처리

  1. temperatureis heated
  2. temperatureThe reaction mixture is cooled
  3. extractionextracted with diethyl ether
  4. washThe organic layer is washed with water
  5. dry with materialdried over sodium sulfate
  6. customevaporated

출처 및 근거

ORD 기록
ord-41e789ef8c1144c2a2c531ef8c2002fc
출처 데이터셋
uspto-grants-1989_09
특허 번호
US04870074

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