Triethylamine → 4-Thiazolemethanol, 2-ethynyl-(9CI)

HRID 1608540노트

반응식

HRID 1608540 반응식
Br[C:2]1[S:3][CH:4]=[C:5]([CH2:7][OH:8])[N:6]=1.[Cl-].[NH4+].[CH2:11](N(CC)CC)[CH3:12]>[Cu](I)I.[Pd](Cl)Cl.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>[C:11]([C:2]1[S:3][CH:4]=[C:5]([CH2:7][OH:8])[N:6]=1)#[CH:12]

참가 물질

6

반응물 3

HCID 8471TriethylamineHCID 25517Ammonium ChlorideHCID 2763211(2-Bromo-1,3-thiazol-4-yl)methanol

생성물 1

HCID 450793284-Thiazolemethanol, 2-ethynyl-(9CI)

시약·촉매·용매 2

HCID 83717Copper iodide촉매HCID 6102075Dichlorobis(triphenylphosphine)palladium촉매

실험 절차

2-bromo 4-thiazolyl methanol of preparation 39 was reacted with trimethylacetylene in the presence of copper iodide, bis(triphenylphosphine) palladium chloride and triethylamine and then the mixture was poured into an aqueous solution of ammonium chloride to obtain the expected alcohol.

출처 및 근거

ORD 기록
ord-6b8b2977c0c04148a5728397ca6830b2
출처 데이터셋
uspto-grants-1995_03
특허 번호
US05395845

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