Hydrochloric Acid → 5-[4-(Benzoxazol-2-yl)benzyloxy]tricyclo[3.3.1.13,7]-decan-2-amine hydrochloride
반응식
C([NH:20][CH:21]1[CH:28]2[CH2:29][CH:24]3[CH2:25][C:26]([O:31][CH2:32][C:33]4[CH:38]=[CH:37][C:36]([C:39]5[O:40][C:41]6[CH:47]=[CH:46][CH:45]=[CH:44][C:42]=6[N:43]=5)=[CH:35][CH:34]=4)([CH2:30][CH:22]1[CH2:23]3)[CH2:27]2)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[ClH:48]>>[ClH:48].[O:40]1[C:41]2[CH:47]=[CH:46][CH:45]=[CH:44][C:42]=2[N:43]=[C:39]1[C:36]1[CH:35]=[CH:34][C:33]([CH2:32][O:31][C:26]23[CH2:30][CH:22]4[CH2:23][CH:24]([CH2:29][CH:28]([CH:21]4[NH2:20])[CH2:27]2)[CH2:25]3)=[CH:38][CH:37]=1참가 물질
3
실험 절차
A mixture of N-trityl-5-[4-(benzoxazol-2-yl)benzyloxy]tricyclo[3.3.1.13,7 ]decan-2-amine (200 mg) combined with ethanolic hydrogen chloride (5 ml) is stirred for an hour at room temperature. This is evaporated to dryness and the components separated via flash chromatography (eluting with 10% MeOH/CH2Cl2) to obtain 5-[4-(benzoxazol-2-yl)benzyloxy]tricyclo[3.3.1.13,7 ]-decan-2-amine hydrochloride (m.p. 278°-281° C.).
후처리
- customThis is evaporated to dryness
- customthe components separated via flash chromatography (eluting with 10% MeOH/CH2Cl2)