5-[2-(Amino)ethylthio]imidazo[1,2-a]pyridine dihydrochloride → 5-[2-(Amino)ethylthio]imidazo[1,2-a]pyridine

HRID 1608592

반응식

HRID 1608592 반응식
Cl.Cl.[NH2:3][CH2:4][CH2:5][S:6][C:7]1[N:12]2[CH:13]=[CH:14][N:15]=[C:11]2[CH:10]=[CH:9][CH:8]=1>C(Cl)(Cl)Cl>[NH2:3][CH2:4][CH2:5][S:6][C:7]1[N:12]2[CH:13]=[CH:14][N:15]=[C:11]2[CH:10]=[CH:9][CH:8]=1

참가 물질

3

반응물 1

HCID 233628335-[2-(Amino)ethylthio]imidazo[1,2-a]pyridine dihydrochloride

생성물 1

HCID 152293695-[2-(Amino)ethylthio]imidazo[1,2-a]pyridine수율 99.7%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

After a suspension of 5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine.dihydrochloride (13.31 g, 50 mmoles) in chloroform (200 ml) was washed with 3N-sodium hydroxide (50 ml), the aqueous layer was extracted with chloroform, combined the chloroform layer was dried over anhydrous magnesium sulfate. After the solvent was distilled off to obtain 9.63 g of the desired product (99.7%, pale yellow oily product).

후처리

  1. washwas washed with 3N-sodium hydroxide (50 ml)
  2. extractionthe aqueous layer was extracted with chloroform
  3. dry with materialwas dried over anhydrous magnesium sulfate
  4. distillationAfter the solvent was distilled off

출처 및 근거

ORD 기록
ord-72b5cb6363ac44e39d75f53c9ff1b972
출처 데이터셋
uspto-grants-1995_03
특허 번호
US05395839

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