Hydrochloric Acid → 5-[2-(Amino)ethylthio]-3-nitroimidazo[1,2-a]pyridine,dihydrochloride
반응식
C(OC([NH:8][CH2:9][CH2:10][S:11][C:12]1[N:17]2[C:18]([N+:21]([O-:23])=[O:22])=[CH:19][N:20]=[C:16]2[CH:15]=[CH:14][CH:13]=1)=O)(C)(C)C.[ClH:24]>CO>[ClH:24].[ClH:24].[NH2:8][CH2:9][CH2:10][S:11][C:12]1[N:17]2[C:18]([N+:21]([O-:23])=[O:22])=[CH:19][N:20]=[C:16]2[CH:15]=[CH:14][CH:13]=1참가 물질
4
실험 절차
To a suspension of 5-[2-(tert-butoxycarbonylamino)ethylthio]-3-nitroimidazo[1,2-a]pyridine (364 mg, 1.08 mmoles) in methanol (3 ml) was added conc. hydrochloric acid (2 ml) and the mixture was stirred at room temperature for 1 hour. Then, the solvent was distilled off to obtain 340 mg of the desired product (quantitative, brown solid).
후처리
- distillationThen, the solvent was distilled off
출처 및 근거
- ORD 기록
- ord-eded28059550451b99e2043056287a5a
- 출처 데이터셋
- uspto-grants-1995_03
- 특허 번호
- US05395839
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