5-[2-(Amino)ethylthio]imidazo[1,2-a]pyridine dihydrochloride → 5-[2-(Amino)ethylthio]imidazo[1,2-a]pyridine

HRID 1608636

반응식

HRID 1608636 반응식
Cl.Cl.[NH2:3][CH2:4][CH2:5][S:6][C:7]1[N:12]2[CH:13]=[CH:14][N:15]=[C:11]2[CH:10]=[CH:9][CH:8]=1>C(Cl)(Cl)Cl>[NH2:3][CH2:4][CH2:5][S:6][C:7]1[N:12]2[CH:13]=[CH:14][N:15]=[C:11]2[CH:10]=[CH:9][CH:8]=1

참가 물질

3

반응물 1

HCID 233628335-[2-(Amino)ethylthio]imidazo[1,2-a]pyridine dihydrochloride

생성물 1

HCID 152293695-[2-(Amino)ethylthio]imidazo[1,2-a]pyridine수율 99.7%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

After a suspension of 5-[2(amino)ethylthio]imidazo-[1,2-a]pyridine dihydrochloride (13.31 g, 50 mmloes) in chloroform (200 ml) was washed with 3N sodium hydroxide (50 ml), the aqueous layer was extracted with chloroform, the combined chloroform layer was dried over anhydrous magnesium sulfate. Then, the solvent was distilled off to obtain 9.63 g of the desired product (99.7%, pale yellow oily product).

후처리

  1. washwas washed with 3N sodium hydroxide (50 ml)
  2. extractionthe aqueous layer was extracted with chloroform
  3. dry with materialthe combined chloroform layer was dried over anhydrous magnesium sulfate
  4. distillationThen, the solvent was distilled off

출처 및 근거

ORD 기록
ord-74624a2a1b5b49229391bdcce7eb0e9a
출처 데이터셋
uspto-grants-1995_03
특허 번호
US05395839

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