ethyl 2-(N-phenyl-N-propylamino)acetate → HCID 15225127, 화합물

HRID 1608785

반응식

HRID 1608785 반응식
[C:1]1([N:7]([CH2:11][C:12]([O:14]CC)=[O:13])[CH2:8][CH2:9][CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(O)C.[OH-].[Na+]>[C:1]1([N:7]([CH2:11][C:12]([OH:14])=[O:13])[CH2:8][CH2:9][CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 1

HCID 14060107ethyl 2-(N-phenyl-N-propylamino)acetate

생성물 1

HCID 15225127HCID 15225127, 화합물수율 68%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 14798Sodium Hydroxide용매

실험 절차

To a solution of the product obtained in EXAMPLE 108 (5.0 g) in ethanol (30 ml), 3N aqueous sodium hydroxide (30 ml) was added and the mixture was stirred for 10 minutes under reflux. The aqueous solution was concentrated under reduced pressure and washed with ether, acidified to pH 3 with 2N hydrochloric acid and extracted four times with ethyl acetate. The combined organic layer was washed with saturated sodium chloride, dried over anhydrous sodium sulfate and then concentrated under reduced pressure. The residue was crystallized from ethyl acetate-hexane to give 2.96 g (68%) of the objective compound.

후처리

  1. temperatureunder reflux
  2. concentrationThe aqueous solution was concentrated under reduced pressure
  3. washwashed with ether
  4. extractionextracted four times with ethyl acetate
  5. washThe combined organic layer was washed with saturated sodium chloride
  6. dry with materialdried over anhydrous sodium sulfate
  7. concentrationconcentrated under reduced pressure
  8. customThe residue was crystallized from ethyl acetate-hexane

출처 및 근거

ORD 기록
ord-18dcf2fbcc354b17936cdd9df7f79616
출처 데이터셋
uspto-grants-1995_03
특허 번호
US05397781

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