Water → HCID 23368712, 화합물

HRID 1608849노트

반응식

HRID 1608849 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:17][S:18]([C:21]2[CH:27]=[CH:26][C:24]([CH3:25])=[CH:23][CH:22]=2)(=[O:20])=[O:19])=[C:6]([CH:16]=1)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[Cl:15])=[O:8].[H-].[Na+].[CH3:30]C(C)(Br)C(N)=O.O.[CH3:38][N:39]([CH:41]=[O:42])[CH3:40]>>[S:18]([N:17]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:16][C:6]=1[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[Cl:15])=[O:8])[CH2:30][C:41](=[O:42])[N:39]([CH3:40])[CH3:38])([C:21]1[CH:22]=[CH:23][C:24]([CH3:25])=[CH:26][CH:27]=1)(=[O:19])=[O:20]

참가 물질

6

반응물 5

HCID 962WaterHCID 6228DimethylformamideHCID 24758Sodium hydrideHCID 1012352-Bromo-2-methylpropanamideHCID 23368680N-[4-Chloro-2-(2-chlorobenzoyl)phenyl]-4-methylbenzene-1-sulfonamide

생성물 1

HCID 23368712HCID 23368712, 화합물

실험 절차

8.4 g of 5,2'-dichloro-2-tosylaminobenzophenone are dissolved in 40 ml of DMF and treated with 0.7 g of 80% sodium hydride; after 15 minutes, 10 g of dimethylbromoacetamide, prepared in Example 1, are added and the mixture is stirred overnight at RT. The reaction medium is poured into water, the precipitate formed is filtered off and taken up with DCM and the solution is dried and concentrated. 9.2 g of the expected product are obtained after crystallization from isopropyl ether.

후처리

  1. additionare added
  2. customthe precipitate formed
  3. filtrationis filtered off
  4. customthe solution is dried
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-bb0243ff86c04b5eb05647f0027c16f2
출처 데이터셋
uspto-grants-1995_03
특허 번호
US05397801

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