Sodium borohydride → 2-Cyclobutyl-4-thiazole methanol

HRID 1609331노트

반응식

HRID 1609331 반응식
[BH4-].[Na+].C([O:5][C:6]([C:8]1[N:9]=[C:10]([CH:13]2[CH2:16][CH2:15][CH2:14]2)[S:11][CH:12]=1)=O)C>C(O)C>[CH:13]1([C:10]2[S:11][CH:12]=[C:8]([CH2:6][OH:5])[N:9]=2)[CH2:14][CH2:15][CH2:16]1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 54513950Ethyl 2-cyclobutylthiazole-4-carboxylate

생성물 1

HCID 539708732-Cyclobutyl-4-thiazole methanol수율 101.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Sodium borohydride (2.3 g) was added in portions over a 10 min period to an ice cold solution of 6.3 g of 2-cyclobutyl-4-thiazolecarboxylic acid ethyl ester in 100 ml of ethyl alcohol. The ice bath was removed and the reaction mixture stirred at room temperature for 30 hr during which an additional 0.46 g of sodium borohydride was added. The reaction mixture was then diluted with 200 ml of ice water and extracted with ethyl ether. The combined extracts were washed with water, dried (MgSO4) and condensed in vacuo to yield 5.1 g of 2-cyclobutyl-4-thiazole methanol as an oil.

후처리

  1. customThe ice bath was removed
  2. additionwas added
  3. additionThe reaction mixture was then diluted with 200 ml of ice water
  4. extractionextracted with ethyl ether
  5. washThe combined extracts were washed with water
  6. customdried
  7. custom(MgSO4) and condensed in vacuo

출처 및 근거

ORD 기록
ord-b6e6e4147fd74d2584f307bd85b9e15a
출처 데이터셋
uspto-grants-1995_03
특허 번호
US05399702

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