Pyrrolidine → 5-Benzyloxy-2-[2-(1-pyrrolidinyl)ethyl]4-pyridone

HRID 1609649

반응식

HRID 1609649 반응식
[CH2:1]([O:8][C:9]1[C:10](=[O:17])[CH2:11][C:12]([CH:15]=[CH2:16])=[N:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1>O1CCCC1.C(OC(C)C)(C)C>[CH2:1]([O:8][C:9]1[C:10](=[O:17])[CH2:11][C:12]([CH2:15][CH2:16][N:18]2[CH2:22][CH2:21][CH2:20][CH2:19]2)=[N:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 2

HCID 31268PyrrolidineHCID 677480895-Benzyloxy-2-vinyl-4-pyridone

생성물 1

HCID 677480915-Benzyloxy-2-[2-(1-pyrrolidinyl)ethyl]4-pyridone

시약·촉매·용매 2

HCID 7914Diisopropyl Ether용매HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 5-benzyloxy-2-vinyl-4-pyridone (2.90 g) and pyrrolidine (5.33 ml) was heated and refluxed for an hour. The mixture was cooled and diluted with tetrahydrofuran (20 ml) and diisopropyl ether (80 ml). After being stirred for an hour at ambient temperature, the resulting precipitate was collected by filtration, washed with diisopropyl ether and air-dried at ambient temperature to give 5-benzyloxy-2-[2-(1-pyrrolidinyl)ethyl]-4-pyridone (3.79 g).

후처리

  1. temperaturewas heated
  2. temperaturerefluxed for an hour
  3. temperatureThe mixture was cooled
  4. filtrationthe resulting precipitate was collected by filtration
  5. washwashed with diisopropyl ether
  6. customair-dried at ambient temperature

출처 및 근거

ORD 기록
ord-10f54cffd5024a99aff0992064e5c140
출처 데이터셋
uspto-grants-1995_03
특허 번호
US05401734

연결된 노트

불러오는 중…