Pinacol → 2-[5-Chloro-2-(phenylmethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

HRID 16097

반응식

HRID 16097 반응식
[OH:1][C:2]([C:5]([OH:8])([CH3:7])[CH3:6])([CH3:4])[CH3:3].[Cl:9][C:10]1[CH:11]=[CH:12][C:13]([O:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[C:14]([B:16](O)O)[CH:15]=1>C(OCC)C>[Cl:9][C:10]1[CH:11]=[CH:12][C:13]([O:19][CH2:20][C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)=[C:14]([B:16]2[O:8][C:5]([CH3:7])([CH3:6])[C:2]([CH3:4])([CH3:3])[O:1]2)[CH:15]=1

참가 물질

4

반응물 2

HCID 6425Pinacol2회HCID 41987402-Benzyloxy-5-chlorobenzeneboronic acid

생성물 1

HCID 672777732-[5-Chloro-2-(phenylmethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Pinacol (3.24 g) was added to a solution of [5-chloro-2-(phenylmethoxy)phenyl]-boronic acid (6 g) in diethyl ether, and stirred for 24 h. 4 A molecular sieves and pinacol (1.5 g) were added, stirred for a further 24 h. The sieves were filtered and the filtrate was washed with water and brine, then dried (MgSO4) and concentrated in vacuo. Yield 6.8 g.

후처리

  1. stirringstirred for a further 24 h
  2. filtrationThe sieves were filtered
  3. washthe filtrate was washed with water and brine
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-cad92530f2bb4c4bac0ae274992f4d4c
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737135B2

연결된 노트

불러오는 중…