Water → 2-Isopropyl-phenyl acetate

HRID 1609732노트

반응식

HRID 1609732 반응식
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[OH:10])([CH3:3])[CH3:2].C(N(CC)CC)C.[C:18](Cl)(=[O:20])[CH3:19].O>C(OCC)(=O)C>[C:18]([O:10][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[CH:1]([CH3:3])[CH3:2])(=[O:20])[CH3:19]

참가 물질

6

반응물 4

HCID 962WaterHCID 6367Acetyl chlorideHCID 69432-IsopropylphenolHCID 8471Triethylamine

생성물 1

HCID 3462332-Isopropyl-phenyl acetate

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

2-Isopropylphenol (5.0 kg, 36.7 mol) is dissolved in ethyl acetate (20.8 L) and to this is added triethylamine (4.48 kg, 44.1 mmol). This solution is cooled to -12° and to this is added acetyl chloride (3.15 kg, 40.2 tool) over a period of 2.5 hours keeping the temperature below -10°. Triethylamine hydrochloride precipitates immediately. After the addition is complete stirring is continued for 1 hour at 15° at which time a solid mass is formed. This is dissolved by the addition of water (12L). After separation of the layers the organic layer is further washed with water (233 12L) and evaporated in vacuo (50°, 2 Torr) and then at 70°, 2 Torr to give 2-isopropyl-phenyl acetate as a residual amber oil.

후처리

  1. temperatureThis solution is cooled to -12°
  2. customthe temperature below -10°
  3. customTriethylamine hydrochloride precipitates immediately
  4. additionAfter the addition
  5. customa solid mass is formed
  6. customAfter separation of the layers the organic layer
  7. washis further washed with water (233 12L)
  8. customevaporated in vacuo (50°, 2 Torr)

출처 및 근거

ORD 기록
ord-c881b72bff8d493396c44d844ade62e1
출처 데이터셋
uspto-grants-1995_03
특허 번호
US05401772

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