1-Indanone → Indeno(1,2-b)indole

HRID 1609887

반응식

HRID 1609887 반응식
[C:1]1(=O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.Cl.[C:12]1(C)[CH:17]=[CH:16][C:15]([NH:18]N)=[CH:14][CH:13]=1>C(O)C.Cl>[CH:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:4]=1[CH:3]=[C:2]1[C:16]3[CH:17]=[CH:12][CH:13]=[CH:14][C:15]=3[N:18]=[C:1]12

참가 물질

5

반응물 2

HCID 67351-IndanoneHCID 125044-Methylphenylhydrazine monohydrochloride

생성물 1

HCID 12963293Indeno(1,2-b)indole

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 702Ethanol용매

실험 절차

A mixture of 1-indanone (30.6 g, 232 mmol) and p-tolylhydrazine hydrochloride (37.0 g, 233 mmol) in ethanol (350 mL) and aqueous HCl (12 N, 18 mL) are heated to reflux for 90 minutes. The mixture is cooled and filtered, and the solid is washed with ethanol (600 mL) followed by 20% aqueous ethanol (400 mL) and finally hexanes (200 mL). The off-white solid is dried under vacuum (36.5 g, 72%).

후처리

  1. temperatureare heated
  2. temperatureto reflux for 90 minutes
  3. temperatureThe mixture is cooled
  4. filtrationfiltered
  5. washthe solid is washed with ethanol (600 mL)
  6. customThe off-white solid is dried under vacuum (36.5 g, 72%)

출처 및 근거

ORD 기록
ord-82ddc71cd753491c8dcd622bab0152f9
출처 데이터셋
uspto-grants-2006_01
특허 번호
US06982305B2

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