Thionyl Chloride → 3-Fluoro-4-(trifluoromethyl)benzyl chloride
반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[C:10]([F:13])([F:12])[F:11])[CH2:5]O.S(Cl)([Cl:16])=O>C(Cl)(Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[C:10]([F:13])([F:12])[F:11])[CH2:5][Cl:16]참가 물질
4
실험 절차
To absolution of 3-fluoro-4-(trifluoromethyl)benzyl alcohol (10 g, 52 mmol) in chloroform (20 ml) was added thionyl chloride (18.5 ml, 257 mmol) and the mixture was heated under ref lux for 4 hrs. The reaction solution was concentrated. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1) to give 3-fluoro-4-(trifluoromethyl)benzyl chloride (9.52 g, 87%).
후처리
- temperaturethe mixture was heated under ref lux for 4 hrs
- concentrationThe reaction solution was concentrated
- customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1)
출처 및 근거
- ORD 기록
- ord-bb96693162034c8f9ed3547559716fc4
- 출처 데이터셋
- uspto-grants-2006_01
- 특허 번호
- US06982348B2
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