Sodium Hydroxide → 5-Methyl-2-(trifluoromethyl)-3-furancarboxylic acid

HRID 1610326노트

반응식

HRID 1610326 반응식
[CH3:1][C:2]1[O:6][C:5]([C:7]([F:10])([F:9])[F:8])=[C:4]([C:11]([O:13]CC)=[O:12])[CH:3]=1.[OH-].[Na+]>C(O)C>[CH3:1][C:2]1[O:6][C:5]([C:7]([F:8])([F:9])[F:10])=[C:4]([C:11]([OH:13])=[O:12])[CH:3]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 2737208Ethyl 5-methyl-2-(trifluoromethyl)furan-3-carboxylate

생성물 1

HCID 27821835-Methyl-2-(trifluoromethyl)-3-furancarboxylic acid수율 94%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of ethyl 5-methyl-2-(trifluoromethyl)-3-furancarboxylate (25 g, 113 mmol) in ethanol (200 ml) was added 2N aqueous sodium hydroxide solution (61.9 ml, 123.8 mmol) and the mixture was heated under reflux for 45 min. The reaction solution was concentrated, diluted with water (150 ml), and 6N hydrochloric acid was gradually added to adjust to about pH 5. The precipitated crystals were collected by filtration, washed with water to give 5-methyl-2-(trifluoromethyl)-3-furancarboxylic acid (20.5 g, 94%).

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 45 min
  3. concentrationThe reaction solution was concentrated
  4. additiondiluted with water (150 ml), and 6N hydrochloric acid
  5. additionwas gradually added
  6. filtrationThe precipitated crystals were collected by filtration
  7. washwashed with water

출처 및 근거

ORD 기록
ord-fe4b792014ad49a490abfa9ccd3cabf8
출처 데이터셋
uspto-grants-2006_01
특허 번호
US06982348B2

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