Acetic Acid → 2,2,3,3-Tetrafluoro-1,4-benzodioxane-6-carboxylic acid

HRID 1610617노트

반응식

HRID 1610617 반응식
[F:1][C:2]1([F:16])[O:7][C:6]2[CH:8]=C[C:10](C#N)=[CH:11][C:5]=2[O:4][C:3]1([F:15])[F:14].Cl.[C:18]([OH:21])(=[O:20])[CH3:19]>>[F:15][C:3]1([F:14])[O:4][C:5]2[CH:11]=[CH:10][C:19]([C:18]([OH:21])=[O:20])=[CH:8][C:6]=2[O:7][C:2]1([F:1])[F:16]

참가 물질

4

반응물 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 27766192,2,3,3-Tetrafluoro-1,4-benzodioxane-6-carbonitrile

생성물 1

HCID 222614602,2,3,3-Tetrafluoro-1,4-benzodioxane-6-carboxylic acid

실험 절차

To a solution of 2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxine-6-carbonitrile (5.0 g, 21.44 mmol) in acetic acid (20 ml) was added conc. hydrochloric acid (20 ml), and the mixture was heated under reflux overnight. The reaction solution was concentrated, and the precipitated crystals were filtered and washed with water to give the objective substance (4.76 g, 88%).

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux overnight
  3. concentrationThe reaction solution was concentrated
  4. filtrationthe precipitated crystals were filtered
  5. washwashed with water
  6. customto give the objective substance (4.76 g, 88%)

출처 및 근거

ORD 기록
ord-7554ad90166e47ef946e168e466b3561
출처 데이터셋
uspto-grants-2006_01
특허 번호
US06982348B2

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