Sodium borohydride → HCID 57446332, 화합물

HRID 1610687노트

반응식

HRID 1610687 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1/[CH:8]=[CH:9]/[C:10](=[O:17])[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13].[BH4-].[Na+]>C(O)C.O>[OH:17][CH:10](/[CH:9]=[CH:8]/[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[CH3:1])[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13]

참가 물질

5

반응물 2

HCID 4311764Sodium borohydrideHCID 202607254-Pentenoic acid, 5-(2-methylphenyl)-3-oxo-, eth

생성물 1

HCID 57446332HCID 57446332, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

To a solution of ethyl (E)-5-(2-methylphenyl)-3-oxo-4-pentenoate (37.24 g, 160.3 mmol) in ethanol (100 ml) was added sodium borohydride (3.03 g, 80.2 mmol) by small portions under ice-cooling, and the mixture was stirred as it was for 10 min. The reaction solution was diluted with water, and extracted twice with ethyl acetate. The recovered organic layer was dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure to give a crude product of ethyl (E)-3-hydroxy-5-(2-methylphenyl)penta-4-enoate as a yellow liquid.

후처리

  1. temperaturecooling
  2. extractionextracted twice with ethyl acetate
  3. dry with materialThe recovered organic layer was dried over anhydrous sodium sulfate
  4. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-b9dcd96d39394dacb809a63cfb4f3fda
출처 데이터셋
uspto-grants-2006_01
특허 번호
US06982348B2

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