Hydrochloric Acid → HCID 22258297, 화합물

HRID 1610826노트

반응식

HRID 1610826 반응식
FC1C=CC=CC=1C([O:6][C:7]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[F:31])=[CH:8][C:9]1[N:10](C(=O)C2C=CC=CC=2F)[C:11]([CH3:15])=[C:12]([CH3:14])[N:13]=1)=O.O.[ClH:37]>>[ClH:37].[CH3:14][C:12]1[N:13]=[C:9]([CH2:8][C:7]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[F:31])=[O:6])[NH:10][C:11]=1[CH3:15]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 695894172-[1-(2-Fluorobenzoyl)-4,5-dimethyl-1H-imidazol-2-yl]-1-(2-fluorophenyl)ethenyl 2-fluorobenzoate

생성물 1

HCID 22258297HCID 22258297, 화합물수율 14%

실험 절차

12.97 g crude crude compound of Example V are refluxed 1.5 h in 200 ml concentrated hydrochloric acid. The mixture is cooled to rT and 200 mL water are added. The solution is extracted twice with toluene and the aqueous phase is concentrated under vacuum. The residue is stirred with ethanol, filtered, washed once with ethyl acetate and once with petrol ether and dried to yield 1.04 g (14% of th.) 2-(4,5-Dimethyl-1H-imidazol-2-yl)-1-(2-fluorophenyl)ethanone hydrochloride.

후처리

  1. temperatureThe mixture is cooled
  2. extractionThe solution is extracted twice with toluene
  3. concentrationthe aqueous phase is concentrated under vacuum
  4. filtrationfiltered
  5. washwashed once with ethyl acetate and once with petrol ether
  6. customdried

출처 및 근거

ORD 기록
ord-860b4b6731194912bc23a629ca07c025
출처 데이터셋
uspto-grants-2006_01
특허 번호
US06984646B2

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