Water → 4-methyl-2,3-dihydro-1H-inden-1-ol

HRID 1611003노트

반응식

HRID 1611003 반응식
[BH4-].[Na+].[CH3:3][C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH2:6][CH2:7][C:8]2=[O:13].O>C1COCC1.CO>[CH3:3][C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH2:6][CH2:7][CH:8]2[OH:13]

참가 물질

5

반응물 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 44184314-Methyl-1-indanone

생성물 1

HCID 109863964-methyl-2,3-dihydro-1H-inden-1-ol수율 99%

시약·촉매·용매 1

HCID 21899815MeOH tetrahydrofuran용매

실험 절차

NaBH4 is added, in portions, at 0° C., to the solution of 4-methyl-1-indanone in THF/CH3OH. After 3 hours the mixture is poured into water and extracted with ether. After washing the organic extracts to neutrality and anhydrifying on Na2SO4, the solvent is evaporated under vacuum. 22.0 g of 4-methyl-1-indanol are obtained (yield=99%).

후처리

  1. extractionextracted with ether
  2. washAfter washing the organic extracts to neutrality
  3. customthe solvent is evaporated under vacuum

출처 및 근거

ORD 기록
ord-1306efb484a34773b025cb1886a8f508
출처 데이터셋
uspto-grants-2006_01
특허 번호
US06984703B1

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