Hydrochloric Acid → methyl(L-alanylamino)(cyclopropyl)acetate hydrochloride

HRID 1612320노트

반응식

HRID 1612320 반응식
C(OC([NH:8][C@H:9]([C:11]([NH:13][CH:14]([CH:19]1[CH2:21][CH2:20]1)[C:15]([O:17][CH3:18])=[O:16])=[O:12])[CH3:10])=O)(C)(C)C.[ClH:22]>O1CCOCC1>[ClH:22].[NH2:8][C@H:9]([C:11]([NH:13][CH:14]([CH:19]1[CH2:21][CH2:20]1)[C:15]([O:17][CH3:18])=[O:16])=[O:12])[CH3:10]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 58583288methyl{[N-(tert-butoxycarbonyl)-L-alanyl]amino}(cyclopropyl)acetate

생성물 1

HCID 86588880methyl(L-alanylamino)(cyclopropyl)acetate hydrochloride수율 100%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A solution of methyl {[N-(tert-butoxycarbonyl)-L-alanyl]amino}(cyclopropyl)-acetate (72 mg, 0.24 mmol) in 4 N HCl in dioxane (1 mL) was stirred at rt for 45 min. Concentrate to afford 57 mg (100%) of methyl (L-alanylamino)(cyclopropyl)acetate hydrochloride as a solid: 1H NMR (DMSO-d6) δ 0.42-0.60, 1.21-1.26, 1.68, 3.65-3.91, 4.60, 8.17; MS (ESI+) for C8H12N2O2 m/z 201 (M+H)+.

후처리

  1. concentrationConcentrate

출처 및 근거

ORD 기록
ord-e9f0be14e90c4eed89b5ec59357f14c1
출처 데이터셋
uspto-grants-2006_01
특허 번호
US06992087B2

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