Water → 5-(2-Oxopyrrolidin-1-yl)-biphenyl-3-carboxylic Acid

HRID 1612437노트

반응식

HRID 1612437 반응식
C[O:2][C:3]([C:5]1[CH:6]=[C:7]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:8]=[C:9]([N:11]2[CH2:15][CH2:14][CH2:13][C:12]2=[O:16])[CH:10]=1)=[O:4].[Li+].[OH-].O>O1CCOCC1>[O:16]=[C:12]1[CH2:13][CH2:14][CH2:15][N:11]1[C:9]1[CH:10]=[C:5]([C:3]([OH:4])=[O:2])[CH:6]=[C:7]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:8]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 695897705-(2-Oxopyrrolidin-1-yl)-biphenyl-3-carboxylic Acid Methyl Ester

생성물 1

HCID 222529945-(2-Oxopyrrolidin-1-yl)-biphenyl-3-carboxylic Acid

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To 5-(2-oxopyrrolidin-1-yl)-biphenyl-3-carboxylic acid methyl ester (D10) (23 mg, 0.078 mmol) in dioxane (2 ml) was added LiOH (5 mg, 0.117 mmol) and water (1 ml) and stirred at room temperature for 2 hours. The solvent was then evaporated to dryness and the residue was partitioned between ethyl acetate and water. The aqueous layer was separated and acidified to pH=1. The product precipitated in the aqueous layer and was removed by filtration and dried in vacuo to afford D11 (10 mg) as white solid.

후처리

  1. customThe solvent was then evaporated to dryness
  2. customthe residue was partitioned between ethyl acetate and water
  3. customThe aqueous layer was separated
  4. customThe product precipitated in the aqueous layer
  5. customwas removed by filtration
  6. customdried in vacuo
  7. customto afford D11 (10 mg) as white solid

출처 및 근거

ORD 기록
ord-d90817cd960e4005afaad5d26f2c7547
출처 데이터셋
uspto-grants-2006_01
특허 번호
US06992103B2

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