Lithium Hydroxide → 3-(2-Oxo-1,3-oxazolidin-3-yl)benzoic acid

HRID 1612442노트

반응식

HRID 1612442 반응식
C[O:2][C:3](=[O:16])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N:10]2[CH2:14][CH2:13][O:12][C:11]2=[O:15])[CH:5]=1.[Li+].[OH-]>O1CCOCC1>[O:15]=[C:11]1[N:10]([C:6]2[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=2)[C:3]([OH:16])=[O:2])[CH2:14][CH2:13][O:12]1

참가 물질

4

반응물 2

HCID 3939Lithium HydroxideHCID 695897133-(2-Oxooxazolidin-3-yl)benzoic Acid Methyl Ester

생성물 1

HCID 222530423-(2-Oxo-1,3-oxazolidin-3-yl)benzoic acid수율 60%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

3-(2-Oxooxazolidin-3-yl)benzoic acid methyl ester (D118) (110 mg, 0.5 mmol) in dioxane (2.5 ml) was treated with 1M LiOH solution (0.75 ml) and the mixture was stirred at room temperature for 1.5 h. Amberlyst 15 was then added and stirring continued for 15 mins. The resin was filtered and the filtrate evaporated to dryness. Th residue was tritutated with diethyl ether to afford the title compound (62 mg, 60%).

후처리

  1. additionAmberlyst 15 was then added
  2. stirringstirring
  3. waitcontinued for 15 mins
  4. filtrationThe resin was filtered
  5. customthe filtrate evaporated to dryness

출처 및 근거

ORD 기록
ord-e46ad5cceda64c598328ea23b390abf7
출처 데이터셋
uspto-grants-2006_01
특허 번호
US06992103B2

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