Lithium Hydroxide → 2-Fluoro-3-(2-oxopyrrolidin-1-yl)benzoic Acid

HRID 1612446노트

반응식

HRID 1612446 반응식
C[O:2][C:3](=[O:17])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N:10]2[CH2:14][CH2:13][CH2:12][C:11]2=[O:15])[C:5]=1[F:16].[Li+].[OH-]>>[F:16][C:5]1[C:6]([N:10]2[CH2:14][CH2:13][CH2:12][C:11]2=[O:15])=[CH:7][CH:8]=[CH:9][C:4]=1[C:3]([OH:17])=[O:2]

참가 물질

3

반응물 2

HCID 3939Lithium HydroxideHCID 695899492-Fluoro-3-(2-oxopyrrolidin-1-yl)benzoic Acid Methyl Ester

생성물 1

HCID 222529812-Fluoro-3-(2-oxopyrrolidin-1-yl)benzoic Acid

실험 절차

2-Fluoro-3-(2-oxopyrrolidin-1-yl)benzoic acid methyl ester (D26) (137 mg, 0.58 mmol) was treated with 1M LiOH as described in D25 to afford D27 (85 mg, 66%).

후처리

  1. customto afford D27 (85 mg, 66%)

출처 및 근거

ORD 기록
ord-c92ddf6e629a4cb8a234ba408f4bef2f
출처 데이터셋
uspto-grants-2006_01
특허 번호
US06992103B2

반응 노트

불러오는 중…