m-Chloroperbenzoic acid → Methyl 2-(4-chlorophenyl)oxirane-2-carboxylate
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[CH2:13])[C:9]([O:11][CH3:12])=[O:10])=[CH:4][CH:3]=1.ClC1C=CC=C(C(OO)=[O:22])C=1>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([O:22][CH2:13]2)[C:9]([O:11][CH3:12])=[O:10])=[CH:6][CH:7]=1참가 물질
4
실험 절차
To a solution of 19.6 g of methyl 2-(4-chlorophenyl)acrylate in 200 ml of dry chloroform, under an inert atmosphere are added 47.06 g of 55% m-chloroperbenzoic acid and the resulting solution is refluxed for 18 hours. The mixture is then cooled and the solid removed by filtration. Evaporation in vacuo of the filtrate and chromatography of the residue on silica-gel affords methyl 2-(4-chlorophenyl)-2,3-epoxy-propionate as a colourless oil.
후처리
- temperaturethe resulting solution is refluxed for 18 hours
- temperatureThe mixture is then cooled
- customthe solid removed by filtration
- customEvaporation in vacuo of the filtrate and chromatography of the residue on silica-gel
출처 및 근거
- ORD 기록
- ord-fda53885c7374412b65bdb45a195c0f0
- 출처 데이터셋
- uspto-grants-1993_03
- 특허 번호
- US05190934
반응 노트
불러오는 중…