Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N,N,N-trimethylglycinium → (-)-Carnitine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N,N,N-trimethylglycinium | HCID 248 | — |
| 반응물 | Carnitine Chloride | HCID 5970 | — |
| 반응물 | (2R)-3-Cyano-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride | HCID 200829 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 생성물 | (-)-Carnitine | HCID 10917 | — |
반응 단계
13.5 kg L-carnitine nitrile chloride was dissolved in 22 liters concentrated hydrochloric acid and hydrolyzed to L-carnitine chloride, as described in Example 2. It was subsequently reacted to betaine in the highly basic ion exchanger (Amberlite IRA-416). After appropriate reprocessing, 11.1 kg colorless L-carnitine with (α)D20 =-30.8° and an HPLC concentration of 99.7% was isolated.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05191085 |
| 출처 데이터셋 | uspto-grants-1993_03 |
| ORD ID | ord-62087cc445b44d86996435c802aaa79a |
| 출처 메모 | uspto-grants-1993_03 |