Water → HCID 24838476, 화합물

HRID 1613233노트

반응식

HRID 1613233 반응식
[CH3:1][C:2]1[N:3]=[C:4]([NH:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[S:5][C:6]=1[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][CH:9]=1.O>C(O)C.COC(O)C.[Ni]>[CH3:1][C:2]1[N:3]=[C:4]([NH:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[S:5][C:6]=1[CH2:7][C:8]1[CH:9]=[CH:10][C:11]([NH2:14])=[CH:12][CH:13]=1

참가 물질

5

반응물 2

HCID 962WaterHCID 24838526HCID 24838526, 화합물

생성물 1

HCID 24838476HCID 24838476, 화합물수율 72.8%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 86746606HCID 86746606, 화합물용매

실험 절차

9.2 g of ethyl (4-methyl-5-(4-nitrobenzyl)thiazol-2-yl)aminoacetate in 500 ml of an ethanol/methoxyethanol mixture are hydrogenated at normal pressure and room temperature in the presence of Raney nickel. After filtration of the catalyst and concentration of the reaction medium, a brown oil is obtained which is taken up with acidified water, the aqueous phase is extracted with chloroform and then rendered basic and the precipitate obtained is filtered off to give 6.1 g of ethyl (4-methyl-5-(4-aminobenzyl)thiazol-2-yl)aminoacetate in the form of a brown solid melting at 116° C.

후처리

  1. filtrationAfter filtration of the catalyst and concentration of the reaction medium
  2. customa brown oil is obtained which
  3. extractionthe aqueous phase is extracted with chloroform
  4. customthe precipitate obtained
  5. filtrationis filtered off

출처 및 근거

ORD 기록
ord-eb96a2b7badf488ea8325a712b7613eb
출처 데이터셋
uspto-grants-1993_03
특허 번호
US05192781

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