1-Butanol → n-Butyl-2-(o-phenoxyphenyl)hexanoate

HRID 1613259노트

반응식

HRID 1613259 반응식
[CH2:1]([OH:5])[CH2:2][CH2:3][CH3:4].[CH3:6][CH2:7][CH2:8][CH2:9][CH:10]([C:24]#N)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[O:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.S(=O)(=O)(O)[OH:27]>O>[CH2:1]([O:5][C:24](=[O:27])[CH:10]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[O:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH2:9][CH2:8][CH2:7][CH3:6])[CH2:2][CH2:3][CH3:4]

참가 물질

5

반응물 3

HCID 2631-ButanolHCID 1118Sulfuric AcidHCID 197756142-(2-Phenoxyphenyl)hexanenitrile

생성물 1

HCID 53887059n-Butyl-2-(o-phenoxyphenyl)hexanoate수율 104.9%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Into a 500-ml round bottom flask are placed 77.7 g (1 mole) of n-butanol, 36.5 g (0.14 mole) of δ-n-butyl o-phenoxybenzyl cyanide and 14.4 g (0.45 mole) of conc. sulfuric acid. The mixture is heated to reflux overnight. It is then cooled, poured into water and extracted with toluene. The combined extracts are washed with water and dried over MgSO4. Solvent is evaporated to give 50 g of product.

후처리

  1. customInto a 500-ml round bottom flask are placed
  2. temperatureThe mixture is heated
  3. temperatureto reflux overnight
  4. temperatureIt is then cooled
  5. extractionextracted with toluene
  6. washThe combined extracts are washed with water
  7. dry with materialdried over MgSO4
  8. customSolvent is evaporated

출처 및 근거

ORD 기록
ord-a818d85f8fc1464b89e62463d1091a23
출처 데이터셋
uspto-grants-1993_03
특허 번호
US05192783

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