Hydrochloric Acid → N-(4-dimethylamino-2-butynyl)-2-cyclohexyl-2-hydroxy-2-phenylacetamide hydrochloride

HRID 1613281노트

반응식

HRID 1613281 반응식
[CH3:1][N:2]([CH3:24])[CH2:3][C:4]#[C:5][CH2:6][NH:7][C:8](=[O:23])[C:9]([CH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1)([OH:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[ClH:25]>CO>[ClH:25].[CH3:24][N:2]([CH3:1])[CH2:3][C:4]#[C:5][CH2:6][NH:7][C:8](=[O:23])[C:9]([CH:17]1[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]1)([OH:16])[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 14931303N-(4-dimethylamino-2-butynyl)-2-cyclohexyl-2-hydroxy-2-phenylacetamide

생성물 1

HCID 19775486N-(4-dimethylamino-2-butynyl)-2-cyclohexyl-2-hydroxy-2-phenylacetamide hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of N-(4-dimethylamino-2-butynyl)-2-cyclohexyl-2-hydroxy-2-phenylacetamide (0.48 g) in methanol (5 ml) was added 6.4N methanolic hydrogen chloride (1.5 ml) and the solution was evaporated in vacuo. The oily residue was crystallized from a mixture of isopropyl alcohol and ethyl acetate to give N-(4-dimethylamino-2-butynyl)-2-cyclohexyl-2-hydroxy-2-phenylacetamide hydrochloride (0.3 g).

후처리

  1. customthe solution was evaporated in vacuo
  2. customThe oily residue was crystallized from a mixture of isopropyl alcohol and ethyl acetate

출처 및 근거

ORD 기록
ord-3a566e041a504737b1710f16966b1277
출처 데이터셋
uspto-grants-1993_03
특허 번호
US05192779

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