Pyridine → Nonanamide

반응식

[CH2:1]([NH2:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].N1[CH:14]=[CH:13]C=CC=1.C(OC(=O)C)(=[O:17])C>>[CH2:3]([CH2:2][C:1]([NH2:8])=[O:17])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:13][CH3:14]

참가 물질

반응물 3

HCID 1049Pyridine

HCID 7918Acetic Anhydride

HCID 81271-Heptanamine

생성물 1

HCID 70709Nonanamide수율 96%

실험 절차

Heptylamine (39 g; 0.34 mole was added dropwise to 46.6 g (0.59 mole) of pyridine and 43.4 g (0.43 mole) of acetic anhydride over 30 minutes, and the mixture was further stirred for 2 hours. After the reaction, the mixture was concentrated and extracted by adding water and ether. The ethereal layer was washed successively with a saturated aqueous solution of sodium hydrogen carbonate and then a saturated aqueous solution of sodium chloride, and then dried over anhydrous magnesium sulfate and concentrated to give 51 g of the desired compound yield 96 %).

후처리

customAfter the reaction
concentrationthe mixture was concentrated
extractionextracted
additionby adding water and ether
washThe ethereal layer was washed successively with a saturated aqueous solution of sodium hydrogen carbonate
dry with materiala saturated aqueous solution of sodium chloride, and then dried over anhydrous magnesium sulfate
concentrationconcentrated

출처 및 근거

ORD 기록: ord-92d48506e9a24c0e9213a9fa4487194a
출처 데이터셋: uspto-grants-1993_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05192799

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