2,6-Dichloropyrazine → 6-chloro-N-methyl-N-[(1S)-1-phenylethyl]pyrazin-2-amine

반응식

[CH3:1][NH:2][C@H:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH3:4].Cl[C:12]1[CH:17]=[N:16][CH:15]=[C:14]([Cl:18])[N:13]=1>>[Cl:18][C:14]1[N:13]=[C:12]([N:2]([CH3:1])[C@H:3]([C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH3:4])[CH:17]=[N:16][CH:15]=1

참가 물질

반응물 2

HCID 785042,6-Dichloropyrazine

HCID 2060073(S)-(-)-N,alpha-Dimethylbenzylamine

생성물 1

HCID 588699216-chloro-N-methyl-N-[(1S)-1-phenylethyl]pyrazin-2-amine수율 39%

실험 절차

In an analogous fashion to example 1, N-methyl-N-[(1S)-1-phenylethyl]amine (0.27 g, 2.0 mmol) was condensed with 2,6-dichloropyrazine (0.36 g, 2.4 mmol), to furnish the desired product as a light brown solid (192 mg, 39%).

출처 및 근거

ORD 기록: ord-863f27e57344459eacf6de47048dfb92
출처 데이터셋: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07737143B2

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