Ethylenediamine → 3-(Nitromethyl)-1,2-dihydronaphthalene

HRID 1613656노트

반응식

HRID 1613656 반응식
[CH2:1]1[C:10](=O)[CH2:9][C:8]2[C:3](=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:2]1.C(N)CN.[N+:16]([CH3:19])([O-:18])=[O:17]>>[N+:16]([CH2:19][C:10]1[CH2:1][CH2:2][C:3]2[C:8](=[CH:7][CH:6]=[CH:5][CH:4]=2)[CH:9]=1)([O-:18])=[O:17]

참가 물질

4

반응물 3

HCID 3301EthylenediamineHCID 6375NitromethaneHCID 682662-Tetralone

생성물 1

HCID 153234983-(Nitromethyl)-1,2-dihydronaphthalene

실험 절차

A solution of β-tetralone (Aldrich Chemical Co., Milwaukee, Wis. 53233) (24.5 gm) and ethylenediamine (1.75 gm) in nitromethane (250 ml) was heated at 80° for 16 hours. The reaction mixture was filtered, and the filtrate was evaporated to give a red oil. This was partially purified by elution through a short silica column, eluting with hexane/EtOAc (9:1 v/v). The product was a pink oil (26 gm) which was not purified further but was taken directly for the next reaction.

후처리

  1. filtrationThe reaction mixture was filtered
  2. customthe filtrate was evaporated
  3. customto give a red oil
  4. customThis was partially purified by elution through a short silica column
  5. washeluting with hexane/EtOAc (9:1 v/v)
  6. customwas not purified further
  7. customwas taken directly for the next reaction

출처 및 근거

ORD 기록
ord-9a68f28ed1c54ca8b16b1ad6187bb904
출처 데이터셋
uspto-grants-1993_03
특허 번호
US05194450

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