Hydrochloric Acid → HCID 178478920, 화합물

HRID 1614090노트

반응식

HRID 1614090 반응식
[ClH:1].O.O.[NH2:4][C:5]1[S:6][CH:7]=[C:8]([C:10](=[N:33][O:34][CH:35]([F:37])[F:36])[C:11]([NH:13][C@@H:14]2[C:31](=[O:32])[N:16]3[C:17]([C:28]([O-:30])=[O:29])=[C:18]([CH2:21][N+:22]4[N:23]([CH3:27])[CH:24]=[CH:25][CH:26]=4)[CH2:19][S:20][C@H:15]23)=[O:12])[N:9]=1>O>[ClH:1].[NH2:4][C:5]1[S:6][CH:7]=[C:8]([C:10](=[N:33][O:34][CH:35]([F:36])[F:37])[C:11]([NH:13][C@@H:14]2[C:31](=[O:32])[N:16]3[C:17]([C:28]([O-:30])=[O:29])=[C:18]([CH2:21][N+:22]4[N:23]([CH3:27])[CH:24]=[CH:25][CH:26]=4)[CH2:19][S:20][C@H:15]23)=[O:12])[N:9]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 178480385HCID 178480385, 화합물

생성물 1

HCID 178478920HCID 178478920, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

1N-Hydrochloric acid (3.9 ml) was added to a solution of 7β-[2-(2-aminothiazol-4-yl)-2-(difluoromethoxyimino)acetamido]-3-(2-methyl-1-pyrazolio)methyl-3-cephem-4-carboxylate dihydrate (syn isomer) (2 g) in water (50 ml). The resultant aqueous solution was lyophilized to give 7β-[2-(2-aminothiazol-4-yl)-2-(difluoromethoxyimino)acetamido]-3-(2-methyl-1-pyrazolio)methyl-3-cephem-4-carboxylate hydrochloride (syn isomer) (2.1 g).

출처 및 근거

ORD 기록
ord-8c43de013f864b0cbf345c631ebd45fe
출처 데이터셋
uspto-grants-1993_03
특허 번호
US05194432

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