Camptosar → Irinotecan

HRID 1614850

반응식

HRID 1614850 반응식
[CH3:1][CH2:2][C:3]1[C:12]2[CH2:13][N:14]3[C:19](=[O:20])[C:18]4[CH2:21][O:22][C:23]([C@:25]([OH:28])([CH2:26][CH3:27])[C:17]=4[CH:16]=[C:15]3[C:11]=2[N:10]=[C:9]2[C:4]=1[CH:5]=[C:6]([O:29][C:30]([N:32]1[CH2:37][CH2:36][CH:35]([N:38]3[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]3)[CH2:34][CH2:33]1)=[O:31])[CH:7]=[CH:8]2)=[O:24].O.O.O.Cl.[Na].N[C@H](C(O)=O)CS(=O)(O)=O>CO>[CH3:1][CH2:2][C:3]1[C:12]2[CH2:13][N:14]3[C:19](=[O:20])[C:18]4[CH2:21][O:22][C:23]([C@:25]([OH:28])([CH2:26][CH3:27])[C:17]=4[CH:16]=[C:15]3[C:11]=2[N:10]=[C:9]2[C:4]=1[CH:5]=[C:6]([O:29][C:30]([N:32]1[CH2:33][CH2:34][CH:35]([N:38]3[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]3)[CH2:36][CH2:37]1)=[O:31])[CH:7]=[CH:8]2)=[O:24]

참가 물질

5

반응물 3

HCID 60837CamptosarHCID 72886L-Cysteic acidHCID 5360545Sodium

생성물 1

HCID 60838Irinotecan

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Methanol stock-solutions of irinotecan hydrochloride trihydrate (100 ml, 1.15 mg/ml) and sodium salt of methyl ester of N-all-trans-retinoyl cysteic acid (27 ml, 15 mg/ml) were mixed in a 500 ml round-bottom flask and evaporated in vacuo. 100 ml of water was added to the residue obtained after evaporation and the mixture was stirred until it became clear and transparent (approx. 30 min). The concentration of irinotecan in the obtained solution was 1 mg/ml, corresponding to an irinotecan hydrochloride trihydrate concentration of 1.15 mg/ml. The obtained solution was filtered through 0.2 mm filter and freeze dried. The filtration did not result in reduction of irinotecan concentration.

후처리

  1. customevaporated in vacuo
  2. addition100 ml of water was added to the residue
  3. customobtained
  4. customafter evaporation
  5. customtransparent (approx. 30 min)
  6. filtrationThe obtained solution was filtered through 0.2 mm
  7. filtrationfilter
  8. customfreeze dried
  9. filtrationThe filtration

출처 및 근거

ORD 기록
ord-170cc3a8259f48feaeec895636c2ce05
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08765173B2

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