Water → HCID 66786530, 화합물

HRID 1615055노트

반응식

HRID 1615055 반응식
[CH3:1][C:2]1([CH3:9])[O:6][C@H:5]([CH2:7][OH:8])[CH2:4][O:3]1.[H-].[Na+].CS(OC[C:18]1[CH:23]=[CH:22][N:21]=[C:20]([C:24]([N:26]2[CH2:29][CH:28]([C:30]3[CH:35]=[CH:34][C:33]([O:36][CH2:37][C:38]4[CH:43]=[CH:42][C:41]([CH:44]5[CH2:46][CH2:45]5)=[CH:40][CH:39]=4)=[C:32]([O:47][CH3:48])[CH:31]=3)[CH2:27]2)=[O:25])[CH:19]=1)(=O)=O.O.[CH3:50]N(C=O)C>>[CH:44]1([C:41]2[CH:40]=[CH:39][C:38]([CH2:37][O:36][C:33]3[CH:34]=[CH:35][C:30]([CH:28]4[CH2:29][N:26]([C:24]([C:20]5[CH:19]=[C:18]([C@H:7]([CH:5]6[CH2:4][O:3][C:2]([CH3:9])([CH3:1])[O:6]6)[O:8][CH3:50])[CH:23]=[CH:22][N:21]=5)=[O:25])[CH2:27]4)=[CH:31][C:32]=3[O:47][CH3:48])=[CH:43][CH:42]=2)[CH2:46][CH2:45]1

참가 물질

6

반응물 5

HCID 962WaterHCID 6228DimethylformamideHCID 24758Sodium hydrideHCID 736056(R)-SolketalHCID 59634043HCID 59634043, 화합물2회

생성물 1

HCID 66786530HCID 66786530, 화합물

실험 절차

To a solution of (R)-(−)-2,2-dimethyl-1,3-dioxolan-4-methanol (0.42 mL) in DMF (10 mL) was added NaH (0.14 g). The mixture was stirred at RT for 1 hr. To the mixture was added 2-{3-[4-(4-cyclopropylbenzyloxy)-3-methoxyphenyl]azetidine-1-carbonyl}pyridin-4-ylmethyl methanesulfonate (0.80 g) prepared in (7). The reaction mixture was stirred for at RT for 1 hr. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was washed with water, reduced pressure to give the crude title compound.

후처리

  1. stirringThe reaction mixture was stirred for at RT for 1 hr
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with water, reduced pressure

출처 및 근거

ORD 기록
ord-2aee4bf1dc3e43af89e60c2291d7ff11
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08765739B2

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