[Cl:1][C:2]1[CH:3]=[C:4]([CH:34]=[CH:35][CH:36]=1)[O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:13]=[C:14]([CH:22]3[CH2:27][CH2:26][N:25]([S:28]([CH3:31])(=[O:30])=[O:29])[CH2:24][CH2:23]3)[N:15]3[C:20]=2[C:19]([NH2:21])=[N:18][CH:17]=[N:16]3)=[CH:8][C:7]=1[O:32][CH3:33].[Cl:37]N1C(C)(C)C(=O)N(Cl)C1=O>CN(C=O)C>[Cl:37][C:13]1[C:12]([C:9]2[CH:10]=[CH:11][C:6]([O:5][C:4]3[CH:34]=[CH:35][CH:36]=[C:2]([Cl:1])[CH:3]=3)=[C:7]([O:32][CH3:33])[CH:8]=2)=[C:20]2[N:15]([C:14]=1[CH:22]1[CH2:27][CH2:26][N:25]([S:28]([CH3:31])(=[O:29])=[O:30])[CH2:24][CH2:23]1)[N:16]=[CH:17][N:18]=[C:19]2[NH2:21]The compound (15.40 mg, 0.029 mmol) prepared in Example 26 and 1,3-dichloro-5,5-dimethylimidazolidine-2,4-dione (2.87 mg, 0.015 mmol) were taken up in 2 mL of DMF and heated to 65° C. for 16 hours. The reaction was cooled to room temperature and the DMF removed under vacuum and the reaction mixture submitted for prep-HPLC purification to obtain the title compound (12.8 mg) having the following physical data.
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