Sodium Hydroxide → 2-(1-(Tert-butoxycarbonyl)-3-(3-methoxyphenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)ethanoic acid

HRID 1615745노트

반응식

HRID 1615745 반응식
[OH-:1].[Na+].[CH3:3][O:4][C:5]1[CH:6]=[C:7]([CH:11]2[NH:16][C:15](=[O:17])[C:14]3([CH2:23][O:22][CH2:21][CH2:20][O:19][CH2:18]3)[N:13]([C:24]([O-:26])=[O:25])[CH2:12]2)[CH:8]=[CH:9][CH:10]=1>CO>[C:7]([O:25][C:24]([N:13]1[C:14]2([CH2:18][O:19][CH2:20][CH2:21][O:22][CH2:23]2)[C:15](=[O:17])[N:16]([CH2:10][C:5]([OH:4])=[O:1])[CH:11]([C:7]2[CH:8]=[CH:9][CH:10]=[C:5]([O:4][CH3:3])[CH:6]=2)[CH2:12]1)=[O:26])([CH3:11])([CH3:8])[CH3:6]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 866685383-(3-Methoxyphenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecane-1-carboxylate

생성물 1

HCID 681545282-(1-(Tert-butoxycarbonyl)-3-(3-methoxyphenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)ethanoic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2.5 ml (2.5 mmol) of a 1N aqueous sodium hydroxide solution were added to 0.38 g (0.82 mmol) tert-butyl (3-(3-methoxyphenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecane-1-carboxylate in 5 ml MeOH. After 1 h MeOH was distilled off and the aqueous solution was acidified with 1N hydrochloric acid. The aqueous phase was extracted with ethyl acetate. The ethyl acetate phase was dried and evaporated down.

후처리

  1. distillationAfter 1 h MeOH was distilled off
  2. extractionThe aqueous phase was extracted with ethyl acetate
  3. dry with materialThe ethyl acetate phase was dried
  4. customevaporated down

출처 및 근거

ORD 기록
ord-089c3ab1ce06404bbc9af6afb650d212
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08765763B2

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