Hydrochloric Acid → (R)-methyl 2-(3-(3,5-difluorophenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)acetate hydrochloride

HRID 1615765노트

반응식

HRID 1615765 반응식
[F:1][C:2]1[CH:3]=[C:4]([C@H:9]2[N:14]([CH2:15][C:16]([O:18][CH3:19])=[O:17])[C:13](=[O:20])[C:12]3([CH2:26][O:25][CH2:24][CH2:23][O:22][CH2:21]3)[N:11](C(OC(C)(C)C)=O)[CH2:10]2)[CH:5]=[C:6]([F:8])[CH:7]=1.[ClH:34]>>[ClH:34].[F:8][C:6]1[CH:5]=[C:4]([C@H:9]2[N:14]([CH2:15][C:16]([O:18][CH3:19])=[O:17])[C:13](=[O:20])[C:12]3([CH2:21][O:22][CH2:23][CH2:24][O:25][CH2:26]3)[NH:11][CH2:10]2)[CH:3]=[C:2]([F:1])[CH:7]=1

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 68154574tert-butyl (R)-3-(3,5-difluoro-phenyl)-4-methoxycarbonylmethyl-5-oxo-8,11-dioxa-1,4-diaza-spiro[5.6]dodecane-1-carboxylate

생성물 1

HCID 68154674(R)-methyl 2-(3-(3,5-difluorophenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)acetate hydrochloride

반응 조건

온도
50 °C

실험 절차

0.13 g (0.28 mmol) tert-butyl (R)-3-(3,5-difluoro-phenyl)-4-methoxycarbonylmethyl-5-oxo-8,11-dioxa-1,4-diaza-spiro[5.6]dodecane-1-carboxylate were combined with 20 ml of a 1M methanolic hydrochloric acid solution and stirred for 2 h at 50° C. The reaction mixture was concentrated by rotary evaporation and further reacted without any further purification.

후처리

  1. concentrationThe reaction mixture was concentrated by rotary evaporation
  2. customfurther reacted without any further purification

출처 및 근거

ORD 기록
ord-f635bd57fb15454dbdaabded8c7ea9e0
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08765763B2

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