Dimethylamine → HCID 44539633, 화합물

HRID 1616028노트

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HRID 1616028 반응식
[Cl:1][C:2]1[N:7]=[C:6]([C:8]([NH:10][C:11]2[CH:19]=[C:18]([C:20]3[CH:28]=[CH:27][CH:26]=[C:25]4[C:21]=3[CH:22]=[CH:23][NH:24]4)[CH:17]=[C:16]3[C:12]=2[CH:13]=[N:14][NH:15]3)=[O:9])[C:5](F)=[CH:4][CH:3]=1.[CH3:30][NH:31][CH3:32].CCN(C(C)C)C(C)C>C1COCC1>[Cl:1][C:2]1[N:7]=[C:6]([C:8]([NH:10][C:11]2[CH:19]=[C:18]([C:20]3[CH:28]=[CH:27][CH:26]=[C:25]4[C:21]=3[CH:22]=[CH:23][NH:24]4)[CH:17]=[C:16]3[C:12]=2[CH:13]=[N:14][NH:15]3)=[O:9])[C:5]([N:31]([CH3:32])[CH3:30])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 674DimethylamineHCID 81531DiisopropylethylamineHCID 44540868HCID 44540868, 화합물

생성물 1

HCID 44539633HCID 44539633, 화합물수율 201.8%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
160 °C

실험 절차

6-Chloro-3-fluoro-N-[6-(1H-indol-4-yl)-1H-indazol-4-yl]-2-pyridinecarboxamide (188 mg, 0.46 mmol) was placed in a microwave vial and dissolved in THF (4 ml). Dimethylamine (0.463 ml, 0.93 mmol) and DIPEA (0.485 ml) were added and the mixture was heated at 160° C. for 1 h under microwave irradiation. The solvent was removed in vacuo and the yellow residue was dissolved in DCM (10 ml) and washed with water (10 ml). The DCM was removed in vacuo and the solid was dried in vacuo on a high vacuum line to afford the title compound (400 mg) as a yellow solid.

후처리

  1. customThe solvent was removed in vacuo
  2. dissolutionthe yellow residue was dissolved in DCM (10 ml)
  3. washwashed with water (10 ml)
  4. customThe DCM was removed in vacuo
  5. customthe solid was dried in vacuo on a high vacuum line

출처 및 근거

ORD 기록
ord-d746b15010074701a5bbe3ffd3df1833
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08765743B2

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