Hydrochloric Acid → Methyl 2-(4-(2-(3-(2-amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)propylamino)-2-oxoethyl)phenyl)acetate

HRID 1617169노트

반응식

HRID 1617169 반응식
[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH2:9][CH2:10][CH2:11][NH:12][C:13](=[O:25])[CH2:14][C:15]2[CH:20]=[CH:19][C:18]([CH2:21][C:22]([OH:24])=[O:23])=[CH:17][CH:16]=2)=[C:4]([NH:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[N:3]=1.Cl.[CH3:33]O>O1CCOCC1>[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH2:9][CH2:10][CH2:11][NH:12][C:13](=[O:25])[CH2:14][C:15]2[CH:20]=[CH:19][C:18]([CH2:21][C:22]([O:24][CH3:33])=[O:23])=[CH:17][CH:16]=2)=[C:4]([NH:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[N:3]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 68415389{4-[2-({3-[2-Amino-4-methyl-6-(pentylamino)pyrimidin-5-yl]propyl}amino)-2-oxoethyl]phenyl}acetic acid

생성물 1

HCID 42613075Methyl 2-(4-(2-(3-(2-amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)propylamino)-2-oxoethyl)phenyl)acetate

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

The product from step (i) was dissolved in MeOH (20 mL) then a solution of HCl in dioxane (4M, 0.3 ml) was added and stirred overnight. Solvent was removed and the residue purified by RPHPLC to afford the title compound, 0.032 g.

후처리

  1. customSolvent was removed
  2. customthe residue purified by RPHPLC

출처 및 근거

ORD 기록
ord-3864013422a146228a2f5026f75792b8
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08765939B2

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