Sodium borohydride → (2-Amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methanol
반응식
[BH4-].[Na+].[NH2:3][C:4]1[N:9]=[C:8]([CH3:10])[C:7]([CH:11]=[O:12])=[C:6]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[N:5]=1>CO>[NH2:3][C:4]1[N:9]=[C:8]([CH3:10])[C:7]([CH2:11][OH:12])=[C:6]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[N:5]=1참가 물질
4
실험 절차
Sodium borohydride (0.6 g) was added to a solution of the product from step (ii) (2 g) in MeOH (30 ml) at 0-5° C. The mixture was warmed to rt, stirred for 3 h then the solvent evaporated under reduced pressure. The residue was partitioned between EtOAc and brine, the organics separated, dried and evaporated under reduced pressure to afford the subtitle compound, 1.78 g.
후처리
- customthe solvent evaporated under reduced pressure
- customThe residue was partitioned between EtOAc and brine
- customthe organics separated, dried
- customevaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-99cd473f76d44ccaa447d27da2008ad4
- 출처 데이터셋
- uspto-grants-2014_07
- 특허 번호
- US08765939B2
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