Potassium Cyanide → HCID 178433372, 화합물

HRID 1617205노트

반응식

HRID 1617205 반응식
[C-:1]#[N:2].[K+].Cl.[NH2:5][C:6]1[N:11]=[C:10]([OH:12])[C:9]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20]Cl)=[CH:16][CH:15]=2)=[C:8]([CH3:22])[N:7]=1>CN(C=O)C.CS(C)=O>[NH2:5][C:6]1[N:11]=[C:10]([OH:12])[C:9]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][C:1]#[N:2])=[CH:16][CH:15]=2)=[C:8]([CH3:22])[N:7]=1

참가 물질

5

반응물 2

HCID 9032Potassium CyanideHCID 178433371HCID 178433371, 화합물

생성물 1

HCID 178433372HCID 178433372, 화합물

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 6228Dimethylformamide용매

실험 절차

Potassium cyanide (2 g) was added to a solution of the product from step (ii) in DMF (20 ml) and DMSO (10 ml) and the mixture stirred at rt for 18 h. The mixture was flushed with nitrogen for 20 min, then diluted with brine (80 ml), stirred for 10 min and the precipitate filtered, washed with water then ether and dried to afford the subtitle compound, 2.46 g.

후처리

  1. customThe mixture was flushed with nitrogen for 20 min
  2. additiondiluted with brine (80 ml)
  3. stirringstirred for 10 min
  4. filtrationthe precipitate filtered
  5. washwashed with water
  6. dry with materialether and dried

출처 및 근거

ORD 기록
ord-2ea4a16d71b64e6e97ad915f5099e11a
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08765939B2

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