(S)-3-aminohexan-1-ol → (S)-2-(3-((2-Amino-4-(1-hydroxyhexan-3-ylamino)-6-methylpyrimidin-5-yl)methyl)-4-fluorophenyl)acetonitrile

HRID 1617211

반응식

HRID 1617211 반응식
[NH2:1][C@@H:2]([CH2:6][CH2:7][CH3:8])[CH2:3][CH2:4][OH:5].[NH2:9][C:10]1[N:15]=[C:14](Cl)[C:13]([CH2:17][C:18]2[CH:19]=[C:20]([CH2:25][C:26]#[N:27])[CH:21]=[CH:22][C:23]=2[F:24])=[C:12]([CH3:28])[N:11]=1>C(O)CCC>[NH2:9][C:10]1[N:15]=[C:14]([NH:1][C@@H:2]([CH2:6][CH2:7][CH3:8])[CH2:3][CH2:4][OH:5])[C:13]([CH2:17][C:18]2[CH:19]=[C:20]([CH2:25][C:26]#[N:27])[CH:21]=[CH:22][C:23]=2[F:24])=[C:12]([CH3:28])[N:11]=1

참가 물질

4

반응물 2

HCID 11062353(S)-3-aminohexan-1-olHCID 866334102-(3-((2-Amino-4-chloro-6-methylpyrimidin-5-yl)methyl)-4-fluorophenyl)acetonitrile

생성물 1

HCID 68956027(S)-2-(3-((2-Amino-4-(1-hydroxyhexan-3-ylamino)-6-methylpyrimidin-5-yl)methyl)-4-fluorophenyl)acetonitrile

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

(S)-3-Aminohexan-1-ol (101 mg) was added to a stirred solution of the product from step (iv) (100 mg) in butan-1-ol (2 mL). The reaction was performed in a microwave, at 18° C. for 2 h. The solvent was removed and the crude product was purified using chromatography, to give the subtitle compound, 70 mg.

후처리

  1. customThe solvent was removed
  2. customthe crude product was purified

출처 및 근거

ORD 기록
ord-e079734426b64738864890d3027b7891
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08765939B2

연결된 노트

불러오는 중…