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Potassium Cyanide → 2-(4-((2-Amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-3-methoxyphenyl)acetonitrile

HRID 1617248
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HRID 1617248 반응식
[C-:1]#[N:2].[K+].[CH2:4]([NH:8][C:9]1[C:14]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([CH2:22]Cl)=[CH:18][C:17]=2[O:24][CH3:25])=[C:13]([CH3:26])[N:12]=[C:11]([NH2:27])[N:10]=1)[CH2:5][CH2:6][CH3:7]>CN(C=O)C.CS(C)=O.CCOC(C)=O.C([O-])(O)=O.[Na+]>[NH2:27][C:11]1[N:10]=[C:9]([NH:8][CH2:4][CH2:5][CH2:6][CH3:7])[C:14]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([CH2:22][C:1]#[N:2])=[CH:18][C:17]=2[O:24][CH3:25])=[C:13]([CH3:26])[N:12]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 2

HCID 9032Potassium CyanideHCID 68413953N4-Butyl-5-(4-(chloromethyl)-2-methoxybenzyl)-6-methylpyrimidine-2,4-diamine

생성물 1

HCID 689572822-(4-((2-Amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-3-methoxyphenyl)acetonitrile

시약·촉매·용매 4

HCID 679Dimethyl Sulfoxide용매HCID 6228Dimethylformamide용매
HCID 8857
Ethyl Acetate
용매
HCID 516892Sodium Bicarbonate용매

실험 절차

KCN (0.844 g) was added to a stirred solution of the product from step (iv) (2.78 g) in DMF (10 mL) and DMSO (10 mL). The mixture was stirred at rt for 15 h. The reaction mixture was diluted with EtOAc (100 mL) and sat. NaHCO3 (100 mL). The organic phase was separated, dried and solvent removed to give the subtitle compound as a solid, 2.2 g.

후처리

  1. customThe organic phase was separated
  2. customdried
  3. customsolvent removed

출처 및 근거

ORD 기록
ord-83fc484fdb26402f93d4549e16168c85
출처 데이터셋
uspto-grants-2014_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08765939B2

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